Comparative analysis of monocyte distribution width alterations in <i>Escherichia coli</i> sepsis: insights from <i>in vivo</i> and <i>ex vivo</i> models
Our findings confirm the clinical utility of MDW in sepsis diagnosis and sustain the reliability of the whole blood assay as <i>ex vivo</i> sepsis model. <i>E. coli</i> and LPS directly promote early monocyte morpho-functional modifications, mirrored by high MDW values and pro-inflammatory mediators. These results improve the knowledge on the biological basis of sepsis, providing novel evidence on the usefulness of MDW in septic conditions.
Authors
- Elena Sukhacheva (ORCID: https://orcid.org/0000-0002-2854-4742)
- Chiara Della Franca
- Daniela Ligi (ORCID: https://orcid.org/0000-0002-5546-8765)
- Giorgio Brandi (ORCID: https://orcid.org/0000-0003-1380-6137)
- Giuditta Fiorella Schiavano (ORCID: https://orcid.org/0000-0002-1427-3486)
- Alba Leis (ORCID: https://orcid.org/0000-0003-3928-7849)
- Ferdinando Mannello (ORCID: https://orcid.org/0000-0001-8112-6139)
- Alicia Martinez‐Iribarren (ORCID: https://orcid.org/0000-0002-1081-1646)
- Michela Pelloso (ORCID: https://orcid.org/0000-0002-2853-4499)
- Francesca Salvatori (ORCID: https://orcid.org/0000-0001-8950-9978)
- Elena Fabbri (ORCID: https://orcid.org/0000-0002-9445-1886)
Institutions
- University of Padua (IT)
- University of Urbino (IT)
- Hospital Universitari Germans Trias i Pujol (ES)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1515/cclm-2025-0487
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35