Impact of Surgical Ventricular Entry on Survival Outcomes in IDH-Mutant Gliomas
This study indicates that VE is associated with poor survival outcomes in IDH-mutant gliomas. These findings warrant prospective studies to better understand the risks, benefits, and mitigation strategies of VE in glioma surgery. Understanding the ependymal physical barrier as well as, cellular biological effects of VE, and its role in glioma tumorigenesis may serve as a basis for potential therapeutic targets in the future management of these patients.
Authors
- Megan Mantica (ORCID: https://orcid.org/0000-0002-6107-6696)
- Sameer Agnihotri (ORCID: https://orcid.org/0000-0001-6584-3795)
- Pascal Olivier Zinn (ORCID: https://orcid.org/0000-0003-0091-5887)
- Kalil G. Abdullah (ORCID: https://orcid.org/0000-0002-5662-0829)
- Jan Drappatz (ORCID: https://orcid.org/0000-0001-8187-7119)
- Neslihan Nisa Geçici (ORCID: https://orcid.org/0009-0003-5315-8362)
- Ahmed Habib (ORCID: https://orcid.org/0000-0003-4908-6987)
Institutions
- University of Pittsburgh Medical Center (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1227/neu.0000000000003744
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63