Synthesis of novel 1-benzoylhexahydro-2H-pyrrolo[3,4-d]pyrimidine-2,4(3H)-dione
We report an efficient [3+2] cycloaddition involving non-stabilized electron-rich azomethine ylides and 1,3-dibenzoyl-pyrimidine-2,4(1H,3H)-dione. The 1,3-dipole was prepared in situ under TFA catalysis, and we obtained the product in good yield and with full control of the regioselectivity
Authors
- Pavlo V. Melnychuk (ORCID: https://orcid.org/0000-0001-9197-6022)
- Oleh V. Shablykin (ORCID: https://orcid.org/0000-0001-6810-9860)
Institutions
- Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar (UA)
Publication Details
- Journal
- Ukrainica Bioorganica Acta
- Published
- 2025-06-30
- DOI
- https://doi.org/10.15407/bioorganica2025.01.046
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.00