Revealing a Heterozygous FCGR1A Variant in a Patient with Uveal Melanoma and Von Hippel–Lindau Syndrome: A Rare Case Report

Our examination indicated that <i>FCGR1A</i>: c.274C>T (p.Arg92*) may have contributed to the co-occurrence of UM and VHL disease. In the future, <i>FCGR1A</i> could be a promising therapeutic approach for retinal cancer due to its role in several cancers and retinal degeneration. To gain a better understanding of its pathogenesis mechanism, it is recommended to conduct functional analysis using appropriate animal models before using the variant in genetic counseling.