Abstract B069: Qualitative insights on the health-related quality of life of young adults living with chronic Hepatitis B

Abstract Background: Chronic hepatitis B (CHB) is a major cause of progressive liver disease and hepatocellular carcinoma that disproportionately affects foreign-born individuals in the United States. Young adults living with CHB face potential impacts on their social, emotional, and physical functioning while actively managing their disease throughout their lifetime. This qualitative study aims to explore the health-related quality of life of this population. Methods: Semi-structured, in-depth interviews will be conducted with up to 15 young adults living with CHB in the United States. A multidisciplinary team of healthcare providers and public health researchers contributed to the development of the interview guide. Data will be transcribed and coded in MAXQDA. An abductive thematic analysis, drawing on the concepts of health-related quality of life, stigma, and social support, will illuminate participants' experiences of health, illness, and disease management and be contextualized within their social and medical environments. Results: Participants ranged from 22 to 34 years. Preliminary findings indicate that hepatitis B minimally impacts participants’ physical health; however, feelings of uncertainty about their future health are common. In the face of such uncertainty, most describe efforts to live healthfully, including minimizing alcohol use. Guidance from health providers on protecting against long-term liver complications varies based on participant knowledge about hepatitis B and caregiver involvement. Many experience tension around disclosing their condition, balancing fears of stigma with considerations of whether sharing is relevant to their social interactions. Conclusion: Young adults living with CHB strive to live healthfully and maintain control amid feelings of uncertainty concerning progressive liver disease and hepatocellular carcinoma. Despite their lifelong disease management to mitigate these risks, having a chronic condition is one part of a multifaceted identity that shapes their health-related quality of life. Research must continue to understand the lived experiences of young adults to inform future public health interventions and promote patient-provider interactions that support their overall health and well-being. Citation Format: Suzanne J. Block, Jill Owczarzak. Qualitative insights on the health-related quality of life of young adults living with chronic Hepatitis B [abstract]. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr B069.