Predictive genomic medicine enlarges the spectrum of predisposing mutations for head and neck cancers via a panel of 56 genes selected for human neoplasia in Southern Italy: a pilot study
Our results confirm that, similarly to other more studied tumors, predictive genomic medicine can play a crucial role in the early identification of germline mutations in head and neck cancers. This approach should be considered for the early detection of OSCC particularly for individuals at increased risk, e.g., those with a family history of the disease, who may also be candidates for targeted molecular therapies based on their genetic profile.
Authors
- Maria Luisa Marciano (ORCID: https://orcid.org/0000-0003-4095-1022)
- Federica Di Maggio (ORCID: https://orcid.org/0009-0008-5917-1492)
- Francesco Salvatore (ORCID: https://orcid.org/0000-0002-2346-3564)
- Alessandra Calabrese (ORCID: https://orcid.org/0000-0002-2814-5207)
- Giulia Togo
- Franco Ionna (ORCID: https://orcid.org/0000-0002-0512-274X)
- Ettore Pavone (ORCID: https://orcid.org/0000-0003-3400-722X)
- Marcella Nunziato (ORCID: https://orcid.org/0000-0003-1999-4992)
- Giovanni Marino
- Petra Claudia Camilla D’Orsi (ORCID: https://orcid.org/0009-0005-2002-8937)
Institutions
- Federico II University Hospital (IT)
- CEINGE Biotecnologie Avanzate Franco Salvatore (Italy) (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Scuola Superiore Meridionale (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1515/cclm-2025-1159
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85