Outcomes of Critically Ill Adult Patients With Acute Encephalitis

In this cohort study of adults with severe encephalitis requiring intensive care, one-half of patients had an unfavorable outcome at 3 months. Functional recovery at 1 year varied by cause of encephalitis, with patients with autoimmune encephalitis experiencing more favorable outcomes than those with other causes, suggesting a possible role for targeted long-term support in certain cases.

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Publication Details

Journal
JAMA Network Open
Published
2025-09-18
DOI
https://doi.org/10.1001/jamanetworkopen.2025.32478
Citations
2
Primary Topic
Infectious Encephalopathies and Encephalitis
Type
article
Field-Weighted Citation Impact
2.79
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article

Outcomes of Critically Ill Adult Patients With Acute Encephalitis

Julien Lopinto, Thècle Degroote, Sébastien Besset, Ariane Gavaud et al.
2 citations
JAMA Network Open
Infectious Encephalopathies and Encephalitis
2.79
article

Outcomes of Critically Ill Adult Patients With Acute Encephalitis

Julien Lopinto, Thècle Degroote, Sébastien Besset, Ariane Gavaud, Christophe Guervilly, Armand Mekontso Dessap, Clarisse Blayau, Morgan Benaïs, Stéphane Legriel, Francis Kinda, Romain Sonneville, Thibault Creutin, Guillaume Savary, Lionel Kerhuel, Damien Marié, Charles Verney, Camille Couffignal, Paul Masi, Sara Virolle, Laure CALVET, Damien Contou, Luc Haudebourg, Jean Reignier, Minh Q Nguyen Le, Pierre‐Yves Olivier, Marie Lemerle, Sarah Benghanem, Sébastien Clerc, Constance Vuillard, Benjamin Coiffard, Charles Cerf, Julien Dupeyrat, Camille Legouy, Guillaume Franchineau, Robin Déléris, Jean-Christophe Navellou, Adel Maamar, Howard Julien, Hélène Beringuer, Alexis Ferré, Ėlodie Baron, Naïke Bigé, Guillaume Laurichesse, Moustafa Abdel-Nabey, Isabelle Priour, Guillaume Lacave, Driss Laghlam, Pierre Dupland, Nicolas Terzi, Elisabeth Coupez, Noémie Zucman, Paul Henri Wicky, Côme Bureau, Pierre Labroca, Arnaud-Félix Miailhe, Jean Morin, Pierre Asfar, Bertrand Souweine, Giao Lê, Olivier Zambon, Marina Esposito‐Farèse, Philippa C. Lavallée, François Perier, Candice Estellat, Athénaïs Boucly, Marcos Felipe Silva de Sá, Sophie Demeret, Armelle Gilard, Fabrice Uhel, Pierre Jaquet, Clémence Marois, Pedro Cavaleiro, Martin Dres, Grégoire Monseau, Rémi Coudroy, Sébastien Gibot, Carole Schwebel, Pierre Couhault, Thomas Urbina, Lionel Nace, Marie Conrad, Rémy Marnai, Éric Mariotte, Romain Carrillon, Fabrice Sinnah, Guillaume Van Der Meersch, Emmanuel Canet, Kévin Grapin, Paul Jaubert, Jean-Marc Forel, Hélène Vinour, Charles‐Édouard Luyt, Claire Bachelier, François Bagate, Claire Dupuis, Jérémie Lemarie, Inès Bendib, Sami Hraiech, Laura Federici, Nicolas Weiss, Edwige Péju, Marie Lecronier, Lev Volkov, Thomas Baudry, Jean‐François Timsit, Faiza Sayagh, Frédéric Dailler, Romain Arrestier, Hélène Migueres, Simon Bourcier, Jérôme Honnorat, Geoffroy Hariri, Jean‐Pierre Frat, Ségolène Gendreau, Suela Demiri, Maxens Decavèle, Cyril Cadoz, Saad Nseir, Lucie Lefèvre, Alain Cariou, Florence Daviet, Samuel Tuffet, Alexandre Robert, Otto Hartman, Thomas Rambaud, Dimal A. Shah, Mathieu Jozwiak, Arnaud Gacouin, Julien Charpentier, Charlotte Garret, Gaêl Michaud, Florent Gobert, Sandie Mazerand, Guilhem Courte, Guillaume Voiriot, Adrien Joseph, Thomas Ritzenthaler, Simona Presente, Benjamin Rohaut, M. Faure, M.L. Borel, Vibol Chhor, Anne Veinstein, Gregoire Ottavy, Radhia Bouzgarrou, François Philippart, Jean-Daniel CHICHE, Jean-Baptiste Lascarrou, Satar Mortaza, Pauline Lamouche-Wilquin, François Beloncle, Romain Mathiéu, Keyvan Razazi, Damien Roux, Leanna J. Crosby, Pierre Bailly, Guillaume Louis, A. Garin, Clara Vigneron, Cédric Bruel, Laurent Papazian, Marc Pierrot, Julien Demiselle, Mathilde Neuville, Arnaud Wilfrid Thille, Emilio Berti, Rostane Gaci, Tiphaine Girard, Jean‐Paul Mira, Florence Boissier, Jean-Mathias Liteaudon, Olivier Pouly, Brice Benelli, Santiago Freita-Ramos, Safaa Nemlaghi, Morgane Bertrix, Daniel Silva, E. Ghrenassia, Olivier Martin, Frédéric F. Pène, Florian Reizine, F. Joly, Virginie Laurent, Achille Kouatchet, Suela Demiri, Vincent Souday, Pascal Beuret, Maëlle Martin, Élise Morawiec, Amélie Seguin, Albert Cao, Anne Renault, Pierre‐Édouard Bollaert, Laurent Argaud, Sybille Merceron, Marc Tran, Antoine Vieillard-Baron, Alexandra Beurton, Louis‐Marie Dumont, Gwénaël Prat, Julien Mayaux, Lee NGUYEN, Jean-Marie Tonnelier, Fabrice Bruneel, Alain Mercat, Lila Bouadma, Anne-Fleur Haudebourg, Virginie Godard, Mélanie Adda, Bertrand Guidet, Lara Zafrani, Delphine Chatellier, Bao-long Nguyen, Éric Maury, Aurélie Cravoisy-Popovic, Benjamine Sarton, Aurélia Toussaint, Pascale Labedade, Kalioubie Ahmed EL, Marion HALLARD, Jeremy HEBRAUD, Assadi MAKSUD, Françoise THOUY, Hamou Zakaria AIT, Virginie ANZANO
article en
2 citations

Abstract

In this cohort study of adults with severe encephalitis requiring intensive care, one-half of patients had an unfavorable outcome at 3 months. Functional recovery at 1 year varied by cause of encephalitis, with patients with autoimmune encephalitis experiencing more favorable outcomes than those with other causes, suggesting a possible role for targeted long-term support in certain cases.

JAMA Network OpenVol. 8(9)
Université Claude Bernard Lyon 1 (FR), Délégation Paris 5 (FR), Hôpital Necker-Enfants Malades (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Paris Cité (FR), Centre Hospitalier Universitaire de Grenoble (FR), Centre Hospitalier Universitaire de Nantes (FR), Centre Hospitalier Universitaire Henri-Mondor (FR), Centre Hospitalier Universitaire de Toulouse (FR), Sorbonne Université (FR), Institut Necker Enfants Malades (FR), Assistance Publique Hôpitaux de Marseille (FR), Hôpital Louis-Mourier (FR), Centre Hospitalier Universitaire de Besançon (FR), Sorbonne Paris Cité (FR), Hôpital Cochin (FR), Assistance Publique – Hôpitaux de Paris (FR), Hospices Civils de Lyon (FR), Hôpital Roger Salengro (FR), Centre hospitalier Bretagne Atlantique (FR), Centre Hospitalier Universitaire de Poitiers (FR), Centre Hospitalier Universitaire d'Angers (FR), Centre Hospitalier Régional de Metz-Thionville (FR), Hôpital André Mignot (FR), Pitié-Salpêtrière Hospital (FR), Hôpital Edouard Herriot (FR), Centre Hospitalier Universitaire de Clermont-Ferrand (FR), Hôpital Avicenne (FR), Hôpitaux Universitaires Henri-Mondor (FR), Centre Hospitalier Régional Universitaire de Brest (FR), Hôpital Ambroise-Paré (FR), Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR), Centre de Recherche Saint-Antoine (FR), Hôpital Paris Saint-Joseph (FR), Centre Hospitalier Victor Dupouy (FR), Hôpital Purpan (FR), Hôpital Saint-Louis (FR), Hôpital Bichat-Claude-Bernard (FR), Centre Hospitalier Saint-Denis (FR), Chumakov Institute of Poliomyelitis and Viral Encephalitides (RU), Hôpital Foch (FR), Université Grenoble Alpes (FR)
Openalex Percentile: Top 9%
Infectious Encephalopathies and Encephalitis
2.79
DOIOpen Access PDFOpenAlex
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