Prostate-Specific Antigen Levels Among Participants Receiving Annual Testing
In this study, significant intra-individual variability in PSA levels was observed in this large screening cohort, with many elevated values falling below the threshold at the next yearly measurement. These findings suggest the utility of guideline recommendations to confirm elevated PSA results in most patients before performing further diagnostic evaluation and that patients with a prior PSA score above a given biopsy threshold, and no recent PSA scores below that threshold, could proceed to further diagnostic evaluation without repeat testing.
Authors
- Sunny Nalavenkata (ORCID: https://orcid.org/0000-0003-3417-7261)
- Andrew Julian Vickers (ORCID: https://orcid.org/0000-0003-1525-6503)
- Emily Vertosick (ORCID: https://orcid.org/0000-0001-6948-9850)
- Hans Lilja (ORCID: https://orcid.org/0000-0001-5871-7846)
- Nicholas A. Pickersgill (ORCID: https://orcid.org/0000-0001-9902-6603)
- Sigrid Carlsson (ORCID: https://orcid.org/0000-0003-3553-5710)
- Bárbara Vieira Lima Aguiar Melão (ORCID: https://orcid.org/0000-0002-8754-5198)
- James A. Eastham
- Maria Pere
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Lund University (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1001/jamaoncol.2025.3386
- Citations
- 1
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52