Triple-Negative Breast Cancer and Ferroptosis: Expression Profiling of Key Regulatory Genes
The significant downregulation and strong positive correlation of GPX4, ACSL4, and BCAT2 in TNBC tissues suggest coordinated suppression of ferroptosis. These findings highlight the potential of targeting ferroptosis as a novel therapeutic strategy in TNBC and propose these genes as candidate biomarkers for diagnosis and treatment response.
Authors
- Cem Yalaza (ORCID: https://orcid.org/0000-0002-9073-5611)
- Ferah Tuncel (ORCID: https://orcid.org/0000-0001-6506-9461)
- Şerife Efsun Antmen (ORCID: https://orcid.org/0000-0003-1270-2408)
- Sema Erden Ertürk (ORCID: https://orcid.org/0000-0002-1988-8674)
- Necmiye Canacankatan (ORCID: https://orcid.org/0000-0003-3863-962X)
- Mustafa Berkeşoğlu (ORCID: https://orcid.org/0000-0002-5850-5592)
Institutions
- Başkent University (TR)
- Mersin Üniversitesi (TR)
Publication Details
- Journal
- Archives of Medical Science
- Published
- 2025-09-15
- DOI
- https://doi.org/10.5114/aoms/208615
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00