Upfront combination therapy with nintedanib and anti-inflammatory agents for progressive pulmonary fibrosis: a multicentre, single-arm phase 2 study (TOP-ILD)
Early combination therapy with tacrolimus, prednisolone and nintedanib was associated with improved pulmonary function and was well tolerated in previously untreated PPF patients. Our findings suggest the potential of this regimen as an initial treatment strategy, but further validation in larger randomised controlled trials is warranted.
Authors
- Yoshiaki Zaizen (ORCID: https://orcid.org/0000-0003-2274-4599)
- Maki Asami‐Noyama (ORCID: https://orcid.org/0000-0001-5218-6132)
- Kazuya Ichikado (ORCID: https://orcid.org/0000-0002-4840-2450)
- Yuko Waseda (ORCID: https://orcid.org/0000-0002-7120-8517)
- Yasuhiro Kondoh (ORCID: https://orcid.org/0000-0001-7456-5459)
- Osamu Nishiyama (ORCID: https://orcid.org/0000-0002-9163-9605)
- Kazuya Tsubouchi (ORCID: https://orcid.org/0000-0003-0145-8745)
- Hidenori Ichiyasu (ORCID: https://orcid.org/0000-0003-1773-8485)
- Hirofumi Chiba (ORCID: https://orcid.org/0000-0002-7033-3084)
- Noriho Sakamoto (ORCID: https://orcid.org/0000-0002-7577-476X)
- Haruhiko Furusawa (ORCID: https://orcid.org/0000-0002-5569-1051)
- Hiroshi Ishii (ORCID: https://orcid.org/0000-0002-2143-5922)
- Isamu Okamoto (ORCID: https://orcid.org/0000-0002-7587-6096)
- Reoto Takei (ORCID: https://orcid.org/0000-0003-1698-2304)
- Tomoyuki Fujisawa (ORCID: https://orcid.org/0000-0002-8809-1781)
- Kazunori Tobino (ORCID: https://orcid.org/0000-0002-3456-6833)
- Masayuki Hirose (ORCID: https://orcid.org/0000-0002-9115-0885)
- Takashi Ogura (ORCID: https://orcid.org/0000-0002-7445-270X)
- Masaki Okamoto (ORCID: https://orcid.org/0000-0002-9298-3504)
- Tomohisa Baba (ORCID: https://orcid.org/0000-0003-4294-634X)
- Shinyu Izumi
- Masanori Nakanishi
Institutions
- Kurume University (JP)
- University of Fukui (JP)
- Kyushu University (JP)
- Sapporo Medical University (JP)
- Yamaguchi University (JP)
- Wakayama Medical University (JP)
- National Kyushu Medical Center (JP)
- Hamamatsu University School of Medicine (JP)
- Fukuoka University (JP)
- Tokyo Institute of Psychiatry (JP)
- National Center for Global Health and Medicine (JP)
- Saiseikai Kumamoto Hospital (JP)
- Kyushu University Hospital (JP)
- Aso Iizuka Hospital (JP)
- Kanagawa Cardiovascular and Respiratory Center (JP)
- Tosei General Hospital (JP)
- Nagasaki University (JP)
- Kindai University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1183/23120541.00697-2025
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00