Neutrophil Extracellular Traps Are Not Linked to Decompensation, <scp>ACLF</scp> , or Death in Clinically Stable Patients With <scp>ACLD</scp>
Patients with stable ACLD showed increased cf-DNA levels (i.e., NETosis, but also apoptosis/necrosis). However, MPO-DNA as a NETosis-specific marker was comparable to healthy controls. NETosis does not appear to drive disease progression in clinically stable ACLD as it was not linked to endpoints, thereby questioning whether findings obtained in animal models are translatable to humans.
Authors
- Mattias Mandorfer (ORCID: https://orcid.org/0000-0003-2330-0017)
- Michael Schwarz (ORCID: https://orcid.org/0000-0002-2587-1385)
- Peter Quehenberger (ORCID: https://orcid.org/0000-0002-0122-8213)
- Nina Dominik (ORCID: https://orcid.org/0009-0009-4615-915X)
- Benedikt Simbrunner (ORCID: https://orcid.org/0000-0001-8181-9146)
- Rubén Francés (ORCID: https://orcid.org/0000-0001-5105-1201)
- Lukas Hartl (ORCID: https://orcid.org/0000-0003-3398-6120)
- Jelle Adelmeijer (ORCID: https://orcid.org/0000-0003-3693-2750)
- Michael Trauner (ORCID: https://orcid.org/0000-0002-1275-6425)
- Georg Semmler (ORCID: https://orcid.org/0000-0002-0411-166X)
- Ton Lisman (ORCID: https://orcid.org/0000-0002-3503-7140)
- Thomas Reiberger (ORCID: https://orcid.org/0000-0002-4590-3583)
- Benedikt Silvester Hofer (ORCID: https://orcid.org/0000-0003-3403-3372)
- Albert Friedrich Stättermayer (ORCID: https://orcid.org/0000-0003-0737-4091)
- Mathias Jachs (ORCID: https://orcid.org/0000-0003-2871-4147)
- Lorenz Balcar (ORCID: https://orcid.org/0000-0002-6708-3061)
- B Scheiner
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Liver International
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1111/liv.70323
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Österreichische Gesellschaft für Gastroenterologie und Hepatologie