m6A-modified circCD2AP suppressed ferroptosis in bladder cancer by upregulating FOXC1 to promote PARK7 transcriptional activity
METTL3-mediated m6A modification drives circCD2AP overexpression, which is subsequently exported to the cytoplasm with enhanced efficiency mediated by YTHDC1. Cytoplasmic circCD2AP stabilizes FOXC1 mRNA, enabling FOXC1-dependent transcriptional activation of PARK7. This axis suppresses ferroptosis and promotes BCa progression, revealing a novel therapeutic target.
Authors
- Lei Zhou (ORCID: https://orcid.org/0000-0002-9880-5506)
- J.Y. Yang (ORCID: https://orcid.org/0000-0001-6430-5485)
- Kun Yao (ORCID: https://orcid.org/0000-0002-2987-3441)
- Jun Gao (ORCID: https://orcid.org/0009-0004-0781-6077)
- Jinrong Wang
- Jing Tan
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1097/cm9.0000000000003744
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00