Analysis of potential targets of 20S-protopanaxadiol on diabetic nephropathy based on network pharmacology, molecular docking, and experimental validation
PPD potentially alleviates renal fibrosis in db/db mice and HK-2 cells by inhibiting the TGF-β1/Smads pathway, thereby delaying DN progression.
Authors
- Hengchi Yu (ORCID: https://orcid.org/0000-0001-8287-9570)
- Chenfei Li (ORCID: https://orcid.org/0000-0001-9497-4620)
- Ruxuan Zhao (ORCID: https://orcid.org/0000-0002-5236-1612)
- Chifa Ma (ORCID: https://orcid.org/0000-0003-4148-2758)
- Mingxia Yuan (ORCID: https://orcid.org/0000-0001-8127-9709)
- Xin‐Feng Li (ORCID: https://orcid.org/0000-0003-0095-3138)
Institutions
- Capital Medical University (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1080/0886022x.2025.2526688
- Citations
- 1
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81