Success Factors in the Response to the Mpox Epidemic in Guinea

Introduction: Guinea, like other West African countries, reported the emergence of MonkeyPox through its first recorded case in the forestland region. The objective of this research was to study the success factors in the response to the Mpox epidemic in Guinea. Method: This was a cross-sectional study with an analytical aim lasting three (03) months from May 1 to July 31, 2025, focusing on the actors involved in the response in Guinea. The data were collected using a structured questionnaire, and the analysis was carried out using Epi Info version 7 and Stata version 13 software. The search for factors linked to the success of the response was carried out through a step-by-step retrograde multivariate analysis, and the significance threshold was set at 5%. Results: A total of 239 participants were included, and the average age was 38 years. Male participants (52%), nurses (67%) with a secondary education level (54%) and nurses working in the Macenta health district (42%) were the most represented. Regarding factors related to the health system, 95% of participants stated that the Community was informed and sensitized about the disease and about the presence of coordination teams and a rapid response team in 79% and 84%, respectively. A lack of vaccines (98%), medicines (98%) and laboratories (94%) was reported. There are isolation sites (59%) and normative documents (55% on average) with trained staff (96%), but these reports are insufficient (32%). According to multivariate analysis, after adjusting for the order ratio, the presence of a coordination team (OR = 25.4; 95% CI: 4.23 - 251), a rapid response team (OR = 35.5; 95% CI: 3.00 - 776), care staff (OR = 37.3; 95% CI: 3.45 - 611), monitoring staff (OR = 244; 95% CI: 3.49 - 50,932), an isolation site (OR = 8.28; 95% CI: 1.78 - 49.5), adapted equipment (OR = 18.5; 95% CI: 3.79 - 123), and care guides (OR = 86.2; 95% CI: 11.4 - 1242) were strongly associated with the success of the response to Mpox. Conclusion: The success of the Mpox response in Guinea relies on a functional and multisectoral organization. To ensure the sustainability of these gains, it is crucial to strengthen the coordination teams and regularly update the normative documents related to care and surveillance.