The effect of glycolytic enzyme expression and thyroiditis on the aggressiveness of papillary thyroid carcinoma: a retrospective cohort study
Overexpression of LDHA, PKM2, GLUT1, and MCT4 is associated with PTC. CLT is significantly associated with an increased incidence of gross ETE and, paradoxically, with a reduced recurrence rate in PTC. LDHA expression was lower in the presence of CLT, whereas PKM2 remained consistently linked to a higher recurrence rate in its absence. Among the evaluated glycolytic enzymes, PKM2 may serve as a biomarker for recurrence in PTC.
Authors
- Jandee Lee (ORCID: https://orcid.org/0000-0003-4090-0049)
- Won Woong Kim (ORCID: https://orcid.org/0000-0003-3471-2068)
- Kee‐Hyun Nam (ORCID: https://orcid.org/0000-0002-6852-1190)
- Daham Kim (ORCID: https://orcid.org/0000-0003-1871-686X)
- Jin Kyong Kim (ORCID: https://orcid.org/0000-0001-5121-8462)
- Jong Ju Jeong (ORCID: https://orcid.org/0000-0002-4155-6035)
- Woong Youn Chung (ORCID: https://orcid.org/0000-0002-0291-8048)
- Sang‐Wook Kang (ORCID: https://orcid.org/0000-0001-5355-833X)
Institutions
- Ulsan College (KR)
- Yonsei University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
Publication Details
- Journal
- Annals of Surgical Treatment and Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4174/astr.2025.109.3.169
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00