Functional Connectivity Associations With Markers of Disease Progression in <i>GRN</i> Pathogenic Variant Carriers
In asymptomatic carriers, the co-occurrence of hyperconnectivity, high neurofilament light chain, and low gray matter volume suggests that functional hyperconnectivity may portend the onset of clinical decline. These findings point toward hyperconnectivity as an indicator of approaching symptomatic onset.
Authors
- Sandra Weıntraub (ORCID: https://orcid.org/0000-0003-2605-5205)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-1308-646X)
- Irene Litvan (ORCID: https://orcid.org/0000-0002-3485-3445)
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Lorenzo Pasquini (ORCID: https://orcid.org/0000-0002-7899-7061)
- Suvi Häkkinen (ORCID: https://orcid.org/0000-0002-6396-1904)
- Alex J. Lee (ORCID: https://orcid.org/0000-0003-0001-2848)
- Kimiko Domoto‐Reilly (ORCID: https://orcid.org/0000-0002-7396-1633)
- Eric J. Huang (ORCID: https://orcid.org/0000-0002-5381-3801)
- David McFall (ORCID: https://orcid.org/0009-0007-2359-2810)
- Stephanie A. Chu (ORCID: https://orcid.org/0000-0001-5749-2139)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Kristen Fernhoff
- Ian R. Mackenzie (ORCID: https://orcid.org/0000-0003-3875-2972)
- Leonard Petrucelli (ORCID: https://orcid.org/0000-0003-2959-129X)
- Ging‐Yuek Robin Hsiung (ORCID: https://orcid.org/0000-0002-8017-0856)
- Jennifer S. Yokoyama (ORCID: https://orcid.org/0000-0001-7274-2634)
- Maria Luisa Mandelli (ORCID: https://orcid.org/0000-0002-2518-2520)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Virginia E. Sturm (ORCID: https://orcid.org/0000-0002-1717-298X)
- Taru Flagan (ORCID: https://orcid.org/0009-0003-6566-9696)
- Jonathan D. Rohrer (ORCID: https://orcid.org/0000-0002-6155-8417)
- Howard J. Rosen (ORCID: https://orcid.org/0000-0001-9281-7402)
- Leah K. Forsberg (ORCID: https://orcid.org/0000-0003-4086-9598)
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Brian S. Appleby (ORCID: https://orcid.org/0000-0003-2275-3292)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Erik D. Roberson (ORCID: https://orcid.org/0000-0002-1810-9763)
- Katherine P. Rankin (ORCID: https://orcid.org/0000-0002-3611-0848)
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Nupur Ghoshal (ORCID: https://orcid.org/0000-0002-6680-6731)
- Jesse A. Brown (ORCID: https://orcid.org/0000-0002-3139-9451)
- Liwen Zhang (ORCID: https://orcid.org/0000-0003-1593-2778)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0003-1454-8643)
- Suzee E. Lee (ORCID: https://orcid.org/0009-0004-3295-6346)
- Eliana Marisa Ramos
- Adam L. Boxer
- Neill R. Graff‐Radford
- Tatiana Foroud
- Bruce L. Miller
- William W. Seeley
- Daniel H. Geschwind
- Maria Luisa Gorno‐Tempini
Institutions
- Northwestern University (US)
- Mayo Clinic (US)
- Harvard University (US)
- University of British Columbia (CA)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- University of Washington (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- University of California System (US)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Massachusetts General Hospital (US)
- Biogipuzkoa Health Research Institute (ES)
- University Memory and Aging Center (US)
- Occupational Cancer Research Centre (CA)
- UK Dementia Research Institute (GB)
- Onkologikoa (ES)
- Cognitive Neuroimaging Lab (FR)
- Mayo Clinic in Florida (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Indiana University Indianapolis (US)
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/acn3.70170
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Association for Frontotemporal Degeneration
- National Institutes of Health
- National Institute on Aging
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences