Cholesterol Intake and Atorvastatin Modulate SCD1 and ELOVL6 in Rat Retroperitoneal Adipose Tissue
The study showed that a cholesterol-enriched diet increased the SCD1 index, leading to a decrease in SAT as these were used for MUFA synthesis. In contrast, atorvastatin lowered MUFA content, suggesting a protective effect of this compound in the rWAT of hypercholesterolemic rats. Furthermore, atorvastatin increased the expression of SCD1 mRNA and protein but did not affect the SCD1 index.
Authors
- Małgorzata Knapik-Czajka (ORCID: https://orcid.org/0000-0002-6545-5159)
- Jagoda Drąg (ORCID: https://orcid.org/0000-0003-0998-7326)
- Marek Szlósarczyk (ORCID: https://orcid.org/0000-0002-3899-4077)
- Anna Gawędzka (ORCID: https://orcid.org/0000-0002-5009-8494)
- Urszula Hubicka (ORCID: https://orcid.org/0000-0002-0612-7630)
- Małgorzata Belczyk (ORCID: https://orcid.org/0000-0002-0491-6636)
Institutions
- Jagiellonian University (PL)
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1111/fcp.70048
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00