Well‐Defined Rhodium and Iridium Complexes Containing Chiral Cyclic(Alkyl)(Amino)Carbenes for Asymmetric Hydrogenation
A novel class of well‐defined rhodium and iridium complexes containing various chiral cyclic(alkyl)(amino)carbene ( Chi CAAC) ligands has been synthesized and fully characterized. While no enantioselectivity is observed with chiral Rh‐CAAC, the Ir‐CAAC counterparts demonstrate good performances in the asymmetric hydrogenation of various allylic alcohols and derivatives with up to 86% ee. Mechanistic studies, including deuteration experiments, reveal that the reduction proceeds via direct alkene hydrogenation rather than via isomerization.
Authors
- Thierry Roisnel (ORCID: https://orcid.org/0000-0002-6088-4472)
- Marc Mauduit (ORCID: https://orcid.org/0000-0002-7080-9708)
- Rodolphe Jazzar (ORCID: https://orcid.org/0000-0002-4156-7826)
- Nicolas Vanthuyne (ORCID: https://orcid.org/0000-0003-2598-7940)
- Frédérique Morvan (ORCID: https://orcid.org/0000-0001-5517-6263)
- Joanna Wencel‐Delord (ORCID: https://orcid.org/0000-0002-7094-5443)
- Thomas Vivès (ORCID: https://orcid.org/0000-0001-6533-0703)
- Meng Liu (ORCID: https://orcid.org/0009-0000-5001-6439)
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Würzburg (DE)
- University of California San Diego (US)
- École Nationale Supérieure de Chimie de Rennes (FR)
- Centrale Méditerranée (FR)
- Université de Rennes (FR)
Publication Details
- Journal
- ChemistryEurope
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1002/ceur.202500268
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- San Diego State University
- Aix-Marseille Université
- European Commission
- Centre National de la Recherche Scientifique
- Civil Aviation Administration of China
- Julius-Maximilians-Universität Würzburg
- Région Bretagne
- University of California, San Diego