Integrated Mendelian randomization analysis reveals causal relationship between LAMA5 and bladder cancer and its metabolic mechanisms
<i>LAMA5</i> was identified as a novel eQTL-mediated oncogenic gene in BC through influencing cell proliferation, migration, and invasion, with its underlying metabolic mechanism involving inhibition of dihydroorotate levels.
Authors
- Yin Yang
- Yinyan He (ORCID: https://orcid.org/0000-0002-7311-9067)
- Qi Pan (ORCID: https://orcid.org/0000-0002-1852-1387)
- Jifu Ge (ORCID: https://orcid.org/0000-0002-0989-4616)
- Zetao Ding
- Zheng Tang (ORCID: https://orcid.org/0000-0002-8604-5386)
- Weiguang Zhao (ORCID: https://orcid.org/0000-0002-6533-6846)
- Fang Zhang (ORCID: https://orcid.org/0000-0002-7000-554X)
- Zhihong Liu (ORCID: https://orcid.org/0000-0001-6093-0726)
- Yigang Zeng
- Renjie Wang (ORCID: https://orcid.org/0009-0002-9953-8822)
- Zijie Xu
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Współczesna Onkologia
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5114/wo.2025.154061
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00