Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine–Glutathione Axis in Mice

CSE deficiency exacerbates CDHFD-induced impairments of cysteine-GSH antioxidant axis, leading to hepatic oxidative stress and cell death. This indicates that CSE plays a protective role against MASLD development and progression. <i>Antioxid. Redox Signal.</i> 44, 11-23.

Authors

Isao Ishii (ORCID: https://orcid.org/0000-0002-5367-205X)
You Ri Park
Yong Han
Se Young Jang (ORCID: https://orcid.org/0000-0001-9148-9670)
GiBong Jang (ORCID: https://orcid.org/0000-0002-7358-4858)
Kwon Moo Park (ORCID: https://orcid.org/0000-0002-1617-5919)
Min Ji Kim

Institutions

Kyungpook National University Hospital (KR)
Kyungpook National University (KR)
Showa Pharmaceutical University (JP)

Publication Details

Journal: Antioxidants and Redox Signaling
Published: 2025-09-15
DOI: https://doi.org/10.1177/15230864251377735
Citations: 2
Primary Topic: Folate and B Vitamins Research
Type: article
Field-Weighted Citation Impact: 3.34

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article

Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine–Glutathione Axis in Mice

Isao Ishii, You Ri Park, Yong Han, Se Young Jang et al.

Sep 15, 2025

2 citations

Antioxidants and Redox Signaling

Folate and B Vitamins Research

3.34

article

Cystathionine γ-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine–Glutathione Axis in Mice

Isao Ishii, You Ri Park, Yong Han, Se Young Jang, GiBong Jang, Kwon Moo Park, Min Ji Kim

September 15, 2025article en

2 citations

Abstract

CSE deficiency exacerbates CDHFD-induced impairments of cysteine-GSH antioxidant axis, leading to hepatic oxidative stress and cell death. This indicates that CSE plays a protective role against MASLD development and progression. <i>Antioxid. Redox Signal.</i> 44, 11-23.

Antioxidants and Redox SignalingVol. 44(1-3)

Kyungpook National University Hospital (KR), Kyungpook National University (KR), Showa Pharmaceutical University (JP)

Openalex Percentile: Top 7%

Folate and B Vitamins Research

3.34

DOI Source OpenAlex

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