An Efficient H-Reduction Protocol for the Synthesis of Novel (Benz)imidazole-allyl Alcohol and Imidazole-1,3-diol Derivatives
An efficient and practical procedure for the synthesis of two novel series of (benz)-imidazole-allyl alcohol and imidazole-1,3-diol derivatives by regioselective reduction of the corresponding (benz)-imidazole-ketone derivatives using NaBH<sub>4</sub>/CeCl<sub>3</sub>·7H<sub>2</sub>O is herein reported. The target products were obtained in high yields under mild conditions (0 °C) and in EtOH as a green solvent.
Authors
- Farhat Rezgui (ORCID: https://orcid.org/0000-0002-9616-0716)
- Olfa Mhasni (ORCID: https://orcid.org/0009-0002-9931-0895)
- Jalloul Bouajila (ORCID: https://orcid.org/0000-0002-2439-5145)
- Nahla Triaa
- Naziha Châabani
Institutions
- Institut National de la Recherche Agronomique (MA)
- Université Toulouse III - Paul Sabatier (FR)
- Laboratoire de Génie Chimique (FR)
- Institute of Organic Chemistry (PL)
- Tunis El Manar University (TN)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1021/acsomega.5c05122
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00