Analysis of miR-155 Expression in Prostate Cancer Patients

Objective: Prostate cancer is a major global health issue and the second most common cancer in men. Itspathogenesis involves genetic and epigenetic changes, hormonal imbalances, and environmental factors,with deficiencies in double-strand break repair mechanisms playing a critical role. microRNAs (miRNAs) aresmall, non-coding RNA molecules that regulate gene expression post-transcriptionally and are implicatedin cancer-related processes.Methods: microRNA-155 expression was analyzed in paired tumor and normal tissues from 50 patients withpathologically confirmed prostate cancer (PC) using quantitative reverse transcription polymerase chainreaction (qRT-PCR). In addition, clinical parameters such as age, smoking status, diabetes, hypertension,PIRADS scores, and Gleason scores were evaluated for their potential association with miR-155 expression.Results: No statistically significant difference was observed in miR-155 expression between tumor andnormal tissues (P > .05). Moreover, miR-155 levels did not show significant correlation with any of theevaluated clinical factors.Conclusion: These findings suggest that miR-155 may not play a direct role in the development and progression of PC. However, this study contributes to the growing understanding of the relationship betweenPC, DNA repair mechanisms, and miRNA regulation. Further studies with larger cohorts and standardizedmethodologies are needed to clarify the potential of miR-155 as a biomarker or therapeutic target in PC.Cite this article as: Habibi S, Rouhi V, Baykal Koca S, Köseoğlu H, Güven M. Analysis of miR-155 expression in prostate cancerpatients. Cerrahpaşa Med J 2025, 49, 0008, doi: 10.5152/cjm.2025.25008.