Synthesis of indenones <i>via</i> photo-induced radical cascade cyclization of alkynes with alkyl halides
A radical cascade cyclization of aryl ynones with alkyl halides was established to synthesise alkylated indenones in yields of 43 to 83% under metal- and oxidant-free and room temperature conditions. The approach enables the construction of two C-C bonds through a XAT process using <i>n</i>Bu<sub>3</sub>N as XAT catalyst.
Authors
- Xiao Liu (ORCID: https://orcid.org/0000-0002-4137-9366)
- Haipin Zhou (ORCID: https://orcid.org/0000-0003-2961-5829)
- Xiaohu Yang (ORCID: https://orcid.org/0000-0002-5871-7894)
- Zhen Wang (ORCID: https://orcid.org/0000-0003-4134-1779)
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ra05436b
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00