Comparison Between Ct Brain and Optic Nerve Sheath Diameter in Detection of Brain Edema in Ischemic Stroke Cases in Intensive Care Unit

Objective: to study the relationship between RA disease and the IL-23R genetic variation (rs11805303) in a group of Egyptian patients diagnosed as rheumatoid arthritis and its association with disease activity.Patient and Methods: One hundred participants, ranging in age from thirty to sixty years old, 56 of whom had RA and 44 of whom were apparently healthy matched in age and sex with patients.All participants were genotyped using PCR/RFLP for the genetic variation (rs11805303).Data were analyzed through Kruskal-Wallis and Mann-Whitney, chi-square (2), Monte Carlo tests and logistic regression.Results: The prevalence of the rs11805303 TT genotype was 21.4% in RA patients, which is greater than in controls (2.3 %).A much greater association with RA was in the CT genotype (1.77 times) and the TT genotype (5.25 times) compared to the CC genotype. Conclusion:The study found that compared to apparently healthy controls, RA patients are more likely to have the IL-23R rs11805303 TT genetic variation.Additionally, greater levels of anti-CCP were associated with the TT genotype, but higher levels of acute phase reactants and disease activity scores are associated with the CC genotype.