ALTERED INFLAMMATORY CYTOKINES AND MCP-1 CHEMOKINE IN PATIENTS WITH CHRONIC RENAL FAILURE

Chronic kidney disease (CKD) is a worldwide epidemic that impacts about 10% of the population globally. CKD is associated with high levels of blood inflammatory markers. This study aimed to examine the role of inflammation in CKD patients by monitoring changes in inflammatory biomarkers. The samples were taken from 30 CKD individuals and 30 healthy individuals. Kidney function parameters, haemoglobin (Hb) content, electrolytes, and ferritin levels were colourimetrically assessed in serum using a spectrophotometer. Nuclear factor- kappa B (NF-kB), tumour necrosis factor (TNF)-α, interleukin (IL)-6, kidney injury marker (KIM)-1, and monocyte chemoattractant protein (MCP)-1 were measured using enzyme-linked immunosorbent assay. Creatinine, urea, ferritin, KIM-1, NF-kB, TNF-α, IL-6, and MCP-1 increased significantly in the serum of CKD patients compared to healthy individuals. Hb content and estimated glomerular filtration rate declined remarkably in CKD individuals compared to normal subjects. In conclusion, the current study confirmed the role of inflammation in CKD and hence, targeting certain inflammatory pathways may improve the health outcomes.