AI-driven radiogenomic analysis of clear cell renal cell carcinoma: perinephric adipose tissue stranding as a key feature of the NIPAL4-associated imaging pattern
Positive NIPAL4 expression in ccRCC is significantly associated with aggressive CT features-particularly perinephric adipose tissue stranding, ill-defined margins, and renal vein thrombosis. A radiogenomic model based on these features achieved excellent predictive performance (AUC = 0.973), supporting its potential role in non-invasive risk stratification and personalized clinical decision-making.
Authors
- Alessandro Tafuri (ORCID: https://orcid.org/0000-0003-1404-2925)
- Luca Pugliese (ORCID: https://orcid.org/0000-0001-9061-7247)
- Federico Greco (ORCID: https://orcid.org/0000-0002-9477-0238)
- Valerio D'Andrea
- Bruno Beomonte Zobel (ORCID: https://orcid.org/0000-0001-9227-5535)
- Maria Concetta Cataldo
- Carlo Augusto Mallio (ORCID: https://orcid.org/0000-0002-0149-0801)
- Andrea Panunzio (ORCID: https://orcid.org/0000-0002-9756-4632)
Institutions
- Campus Bio Medico University Hospital (IT)
Publication Details
- Journal
- Canadian Journal of Urology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/cju.2025.068390
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00