Investigation of the association between nitric oxide synthase gene variants and NAFLD in adolescents with obesity
While the three functional gene variants of the NOS enzyme did not show a significant difference in terms of genotype between patients and healthy controls, it was determined that both the <i>iNOS</i> rs1060826 gene variant-GG allele was associated with low DBP and HOMA-IR may be higher in those carrying the <i>eNOS</i> rs1799983 gene variant TT genotype in NAFLD (+) patients. The <i>iNOS</i> rs1060826 polymorphism is a potentially important genetic variant that may influence DBP regulation through its effects on nitric oxide production.
Authors
- Sevde Hasanoğlu (ORCID: https://orcid.org/0000-0003-2378-1535)
- İbrahim Kandemir (ORCID: https://orcid.org/0000-0002-1720-9711)
- Yasemin Oyacı (ORCID: https://orcid.org/0000-0002-1338-0087)
- Aylin Yetim (ORCID: https://orcid.org/0000-0002-4059-1760)
- Sacide Pehlıvan (ORCID: https://orcid.org/0000-0003-1272-5845)
- Memduh Şahin (ORCID: https://orcid.org/0000-0002-9453-100X)
- Shahri Khudiyeva (ORCID: https://orcid.org/0000-0002-5697-9217)
Institutions
- Sağlık Bilimleri Üniversitesi (TR)
- Istanbul University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Journal of Pediatric Endocrinology and Metabolism
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1515/jpem-2025-0229
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00