Cross‐Dehydrogenative Coupling Reaction of 4‐Aminophenols with 2‐Naphthols Catalyzed by a Mesoporous Silica‐Supported Oxovanadium Catalyst
Abstract Cross‐dehydrogenative coupling (CDC) reactions offer an atom‐economical approach for synthesizing biaryl compounds by directly forming C─C bonds from the C─H bonds of two aromatic molecules. In this study, the CDC reaction between 4‐aminophenols and 2‐naphthols was successfully catalyzed using a mesoporous silica‐supported oxovanadium catalyst. This reaction involved the catalytic, chemo‐ and regio‐selective oxidation of 4‐aminophenols, with molecular oxygen as the terminal oxidant, eliminating the need for stoichiometric chemical oxidants, thereby making the reaction more environmentally friendly.
Authors
- Tomoya Nishio
- Kwihwan Kobayashi (ORCID: https://orcid.org/0000-0002-5289-8348)
- Yutaro Ito (ORCID: https://orcid.org/0009-0009-7961-2707)
- Kyohei Kanomata (ORCID: https://orcid.org/0000-0002-2251-4665)
- Shuji Akai (ORCID: https://orcid.org/0000-0001-9149-8745)
- Koichiro Masuda (ORCID: https://orcid.org/0000-0002-9926-7308)
- Kengo Kasama (ORCID: https://orcid.org/0000-0002-8157-3104)
- Hiroshi Aoyama (ORCID: https://orcid.org/0000-0001-7915-8975)
- Atsushi Kimishima (ORCID: https://orcid.org/0000-0002-8037-4293)
- Jihoon Moon
- Yasushi Kanzaki
Institutions
- Juntendo University Urayasu Hospital (JP)
- Midorigaoka Hospital (JP)
- University of Toyama (JP)
- National Institute of Advanced Industrial Science and Technology (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1002/ajoc.202500537
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- National Institute of Advanced Industrial Science and Technology
- Tokuyama Science Foundation
- Amano Institute of Technology
- Sekisui Chemical
- Japan Society for the Promotion of Science