Associations of circulating c-reactive protein levels with central Alzheimer’s disease biomarkers
Our study revealed differential associations between circulating CRP levels and central AD biomarkers that varied according to the CRP concentration. Further studies are necessary to elucidate the mechanisms underlying the inverse relationship between circulating CRP and brain Aβ within the clinically normal range, as well as potential aggravating effects of elevated CRP on Aβ-independent neurodegeneration.
Authors
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Bo Kyung Sohn (ORCID: https://orcid.org/0000-0002-1444-1099)
- Musung Keum (ORCID: https://orcid.org/0000-0002-0855-8637)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Hyeji Choi (ORCID: https://orcid.org/0000-0001-8280-3963)
- Yun‐Sang Lee (ORCID: https://orcid.org/0000-0003-1640-2090)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Koung Mi Kang (ORCID: https://orcid.org/0000-0001-9643-2008)
- Hongyoon Choi (ORCID: https://orcid.org/0000-0002-8895-2449)
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-6613-4680)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
- Joon Hyung Jung
- Yoon‐Keun Kim (ORCID: https://orcid.org/0000-0001-7610-7654)
- Sang‐Yong Park (ORCID: https://orcid.org/0000-0003-4822-6503)
- Yen-Ning Huang (ORCID: https://orcid.org/0009-0003-4872-231X)
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Inje University Sanggye Paik Hospital (KR)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Chungbuk National University Hospital (KR)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100368
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16