Is Type 2 Diabetes a Modifiable Risk Factor for the Evolution and Progression of Heart Failure With a Preserved Ejection Fraction?
Taken together, these findings suggest that diabetes-associated HFpEF is mediated primarily through its association with excess adiposity. Diabetes is a modifiable risk factor if treatment is directed toward adiposity rather than hyperglycemia.
Authors
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Barry A. Borlaug (ORCID: https://orcid.org/0000-0001-9375-0596)
- Faiez M. Zannad (ORCID: https://orcid.org/0000-0001-7456-1570)
- Milton Packer (ORCID: https://orcid.org/0000-0003-1828-2387)
- Muthiah Vaduganathan (ORCID: https://orcid.org/0000-0003-0885-1953)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
Institutions
- Brigham and Women's Hospital (US)
- Mayo Clinic (US)
- Inserm (FR)
- University of Mississippi (US)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- National University Heart Centre Singapore (SG)
- Baylor Jack and Jane Hamilton Heart and Vascular Hospital (US)
- Baylor Scott & White Health (US)
- Université de Lorraine (FR)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.jacc.2025.07.052
- Citations
- 8
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 11.11