Sanjad Sackati Syndrome in Five Libyan Children: A Case Series

Sanjad Sakati Syndrome (SSS) is one of the rare congenital disorders. It is characterized by congenital hypoparathyroidism, severe prenatal and postnatal growth retardation, dysmorphic features, and mild to severe intellectual retardation. Reported patients were almost exclusively from the Arabian Peninsula. We report on the first four cases (4girls) and one boy of Sanjad-Sakati Syndrome from the eastern part of Libya. They presented with recurrent attacks of hypocalcemic convulsions, severe growth retardation, and typical dysmorphic features of SSS. All patients came from consanguineous families. They all had a low PTH level, chest x-rays for cardiac size, and an echo were normal, so the diagnosis of Di George syndrome, Kenny-Caffey syndrome, is unlikely. This is the first report of Sanjad Sakati syndrome from Libya. To confirm the disease, there are plans to do a genetic study to provide proper counselling to the families. Only in the fifth case, after being diagnosed clinically, the genetic study was available, and the result was positive, as Sanjad-Sackati syndrome. If the disease is recognized early will lead to proper treatment of patients and prevent associated comorbidities. Pediatricians should consider this condition in the differential diagnosis of any dysmorphic hypocalcemia in children, especially newborns and young infants.