Esketamine versus fentanyl as adjuncts to hepatic hilar nerve block for ambulatory percutaneous liver tumor ablation focusing on respiratory safety: protocol for a randomized controlled trial
This trial aims to provide Level I evidence comparing the respiratory depression risk between esketamine-based and fentanyl-based analgesia during HHNB-guided liver ablation. Should esketamine prove to be demonstrably superior in terms of respiratory safety, HHNB-esketamine has the potential to be a viable treatment option.
Authors
- Jianfei Wei (ORCID: https://orcid.org/0000-0002-2923-0446)
- Bin Yang (ORCID: https://orcid.org/0000-0003-4953-3644)
- Xiao Wang (ORCID: https://orcid.org/0009-0001-0985-3136)
- Jiaying Cai
- Lijuan Yan (ORCID: https://orcid.org/0000-0003-1143-2733)
- Zuo-Bing Zhang (ORCID: https://orcid.org/0009-0004-3846-8052)
Institutions
- First Affiliated Hospital of Xiamen University (CN)
- 175th Hospital of People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-17
- DOI
- https://doi.org/10.3389/fphar.2025.1644029
- Citations
- 1
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Wu Jieping Medical Foundation