The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer Progression
The microbial bile acid 3-oxo-LCA activates FXR signaling in intestinal epithelial cells that inhibits cancer stem cell proliferation and induces apoptosis, highlighting the potential of 3-oxo-LCA for treating intestinal tumorigenesis.
Authors
- Jonathan J. Sze (ORCID: https://orcid.org/0009-0009-1551-469X)
- Tao Huan (ORCID: https://orcid.org/0000-0001-6295-2435)
- Chunmiao Cai (ORCID: https://orcid.org/0000-0003-3692-5120)
- Jiaoyang Jiang (ORCID: https://orcid.org/0000-0001-8445-9924)
- Alisa Hui (ORCID: https://orcid.org/0009-0006-2853-2916)
- Dustin A. Deming (ORCID: https://orcid.org/0000-0003-2394-9836)
- Brian Low (ORCID: https://orcid.org/0009-0000-2807-6208)
- Qiyun Zhu (ORCID: https://orcid.org/0000-0002-3568-6271)
- Cheri A. Pasch (ORCID: https://orcid.org/0009-0005-9683-7378)
- Shirsa Udgata (ORCID: https://orcid.org/0000-0002-1929-8121)
- Henry Secaira-Morocho (ORCID: https://orcid.org/0000-0002-3409-1284)
- Ke Wang
- Xingchen Dong (ORCID: https://orcid.org/0000-0003-4364-4466)
- Fei Sun (ORCID: https://orcid.org/0009-0005-1200-0387)
- Ting Fu (ORCID: https://orcid.org/0000-0001-5164-9465)
Institutions
- University of Wisconsin–Madison (US)
- University of British Columbia (CA)
- University of Wisconsin Carbone Cancer Center (US)
- Arizona State University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3898
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.05