Spatial Cross-talk Modeling of the Tumor Microenvironment Identifies CCR5-Mediated Glia-to-Glia Signaling as a Key Regulator of Brain Metastatic Progression
Glial cells are masterminds of brain metastasis that orchestrate tumor-supportive signals and can be targeted with maraviroc to disrupt the metastatic niche as a safe and effective strategy to halt metastatic progression.
Authors
- Stephen T.C. Wong (ORCID: https://orcid.org/0000-0001-9188-6502)
- Jianting Sheng (ORCID: https://orcid.org/0000-0003-3532-3259)
- Matthew Vasquez (ORCID: https://orcid.org/0000-0001-9319-2686)
- Raksha Raghunathan (ORCID: https://orcid.org/0000-0002-2434-425X)
- Li Yang (ORCID: https://orcid.org/0000-0003-1421-7377)
- Akshjot Puri (ORCID: https://orcid.org/0000-0001-7187-7561)
- Ju Young Ahn (ORCID: https://orcid.org/0000-0002-0946-4157)
- Hong Zhao (ORCID: https://orcid.org/0000-0001-8991-7824)
- Wenjuan Dong (ORCID: https://orcid.org/0009-0004-3237-2041)
Institutions
- Houston Methodist (US)
- Methodist Hospital (US)
- Texas A&M University (US)
- Bryan College (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0237
- Primary Topic
- Mathematical Biology Tumor Growth
- Type
- article
- Field-Weighted Citation Impact
- 0.00