Fmp45 promotes Rad53 dephosphorylation via Ptc2 interaction to attenuate checkpoint signaling and maintain genome stability
These findings elucidate a critical checkpoint-phosphatase coordination mechanism ensuring timely DNA damage recovery and genomic stability, identifying Fmp45 as a key regulator balancing DNA repair fidelity with cell cycle resumption following DSBs.
Authors
- Zhongyi Cong (ORCID: https://orcid.org/0000-0001-8020-3921)
- Xinmin Zhang (ORCID: https://orcid.org/0000-0003-1317-2736)
- Mengyuan Li (ORCID: https://orcid.org/0000-0001-6856-6463)
- Jiayin Li (ORCID: https://orcid.org/0000-0002-2844-1428)
- Jingyuan Jiang
- Chenqi Yan
Institutions
- Jilin University (CN)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.jgeb.2025.100567
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00