Regional Specificity of Cortical Layer 3 Dendritic Spine Deficits in Schizophrenia
L3 dendritic spine density differs by diagnosis and cortical region in SZ. Because dendritic spine size is associated with synaptic stability (large/medium spines) and plasticity (small spines), regional differences in the sizes of affected spines in SZ may reflect differing functional impairments in the primary sensory and association regions of the cortical visual-spatial working memory network.
Authors
- Kenneth N. Fish (ORCID: https://orcid.org/0000-0003-1774-3815)
- Matthew L. MacDonald (ORCID: https://orcid.org/0000-0002-2222-2996)
- David A. Lewis (ORCID: https://orcid.org/0000-0002-3225-6778)
- Robert A. Sweet (ORCID: https://orcid.org/0000-0001-9154-9709)
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.2221
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- National Institute of Mental Health