Relationship between skeletal muscle indicators and clinical outcomes in cystic fibrosis is modified by adiposity and CFTR modulator use: a cross-sectional analysis
Muscle mass, strength, and quality are lower in PwCF than in controls, with muscle strength and quality linked to glucose tolerance. Lung function relationships with muscle mass differ by CFTR modulator use, and excess adiposity attenuates strength-related functional benefits. This study highlights the need for personalized approaches to CF management.
Authors
- William R. Hunt (ORCID: https://orcid.org/0000-0002-1882-7132)
- Thomas R. Ziegler (ORCID: https://orcid.org/0000-0001-9329-1481)
- E. Ivie
- Pichatorn Suppakitjanusant (ORCID: https://orcid.org/0000-0003-1884-9136)
- José Binongo
- Jessica A. Alvarez (ORCID: https://orcid.org/0000-0002-7612-1162)
- Ryan A. Harris (ORCID: https://orcid.org/0000-0002-8826-681X)
- Swati Zaveri (ORCID: https://orcid.org/0009-0005-9414-7592)
- Lucia Gonzalez-Ramirez
- Arlene A. Stecenko
- Chris Driggers
- Tasha M Burley
- Virginia A. Stallings
Institutions
- Texas Tech University (US)
- Children's Hospital of Philadelphia (US)
- Emory University (US)
- Augusta University (US)
- Cystic Fibrosis Foundation (US)
- Prevention Institute (US)
- Augusta University Health (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- American Journal of Clinical Nutrition
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.ajcnut.2025.09.019
- Citations
- 1
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.52