Erythroid Atypical Chemokine Receptor 1 Deficiency Aggravates Immune-Mediated Kidney Disease

Our data demonstrates that erythroid-specific ACKR1 deficiency led to an increased infiltration of the kidney by macrophages with an altered profibrotic phenotype in nephrotoxic serum nephritis, resulting in aggravated kidney disease.

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Publication Details

Journal
Journal of the American Society of Nephrology
Published
2025-09-17
DOI
https://doi.org/10.1681/asn.0000000878
Primary Topic
Erythrocyte Function and Pathophysiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Erythroid Atypical Chemokine Receptor 1 Deficiency Aggravates Immune-Mediated Kidney Disease

Maryna Samus, Maria H. Ulvmar, Antal Rot, Theophilus Umeizudike et al.
Journal of the American Society of Nephrology
Erythrocyte Function and Pathophysiology
article

Erythroid Atypical Chemokine Receptor 1 Deficiency Aggravates Immune-Mediated Kidney Disease

Maryna Samus, Maria H. Ulvmar, Antal Rot, Theophilus Umeizudike, Thomas Kroneis, Igor Novitzky‐Basso, Dagmar Kratky, Katharina Artinger, Konstantin A. Klötzer, Andrea Bacon, Agnes A. Mooslechner, Alexander H. Kirsch, Julia Gutjahr, Nathaly Anto-Michel, Corinna Schabhüttl, Marion J. Pollheimer, Stefan Wernitznig, Elin Hub, Kathrin Eller, Philipp Eller, Alexander R. Rosenkranz, Daniel Leitinger
article en

Abstract

Our data demonstrates that erythroid-specific ACKR1 deficiency led to an increased infiltration of the kidney by macrophages with an altered profibrotic phenotype in nephrotoxic serum nephritis, resulting in aggravated kidney disease.

Journal of the American Society of Nephrology
Uppsala University (SE), Queen Mary University of London (GB), University of Toronto (CA), Medical University of Graz (AT), Lagos University Teaching Hospital (NG), Princess Margaret Cancer Centre (CA), BioTechMed-Graz (AT), Lagos State University Teaching Hospital (NG), Biotechnology Institute Thurgau (CH), William Harvey Research Institute (GB), University of Birmingham (GB)
Openalex Percentile: Top 68%
Erythrocyte Function and Pathophysiology
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