Biologically relevant morpholino nucleoside thio- and dithiophosphates <i>via</i> an oxathiaphospholane approach
We report the efficient synthesis of morpholino nucleoside 6′-O-(α-thiophosphates) and 6′-O-(α,α-dithiophosphates) via the oxathiaphospholane approach. These analogs show low cytotoxicity and high potential for biological and therapeutic use.
Authors
- Arkadiusz Chworoś (ORCID: https://orcid.org/0000-0001-9924-0503)
- Róża Pawłowska (ORCID: https://orcid.org/0000-0002-3123-8949)
- Katarzyna Jastrzębska (ORCID: https://orcid.org/0000-0003-3979-3186)
- Agata Szymańska (ORCID: https://orcid.org/0000-0001-5184-931X)
- Justyna Jakubowska
- Weronika Stępniak
Institutions
- Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nj02865e
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowym Centrum Nauki
- University of Colorado Boulder