Differential Gastric Motility, Gut Hormone, and Appetite Changes Following A Mixed Meal in People With Obesity and Healthy Controls
In the gastric phase, people with obesity show rapid gastric emptying with altered hormone and motility meal responses. In healthy individuals, GIP promotes satiety, and ghrelin and motilin promote hunger through actions on motility. Like GIP, GLP-1 promotes satiety along with trending suppression of gastric motility.
Authors
- Moeen Ud‐din (ORCID: https://orcid.org/0000-0003-4542-1258)
- Khalid Elias (ORCID: https://orcid.org/0000-0001-8037-4800)
- Dominic‐Luc Webb (ORCID: https://orcid.org/0000-0002-6979-9194)
- Hetzel Diaz
- Magnus Sundbom (ORCID: https://orcid.org/0000-0002-6243-2859)
- Per M. Hellström (ORCID: https://orcid.org/0000-0001-8428-0772)
- Darius Javidi
Institutions
- Uppsala University (SE)
- Dartmouth–Hitchcock Medical Center (US)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1111/nmo.70163
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet
- Akademiska Sjukhuset
- Uppsala Universitet