Isolated Pancreatic Sarcoidosis Masquerading as Pancreatic Adenocarcinoma: A Case Report

A 50-year-old man with no known medical history presented with a four-year history of epigastric pain and weight loss. Computed tomography (CT) revealed a mass in the head of the pancreas concerning for adenocarcinoma. The patient twice underwent endoscopic ultrasound (EUS) with biopsy, with inconclusive results. Positron emission tomography (PET) scan revealed localized disease, concerning for malignancy. With no definitive diagnosis or treatment options, and after multidisciplinary discussion, the patient underwent a Whipple procedure. Pathology revealed granulomatous inflammation of the pancreas and surrounding lymph nodes, consistent with sarcoidosis. Here, we present a rare case of isolated pancreatic sarcoidosis masquerading as pancreatic malignancy in a patient without a known history of sarcoidosis.