Expression of Estrogen and Progesterone Receptor In Perimenopausal and Postmenopausal Endometrium.

Background: Hormonal changes during the menopausal transition significantly influence breast tissue biology. Estrogen receptor (ER) and progesterone receptor (PR) expression are critical markers in breast pathology and significantly impact prognosis and treatment in hormone-responsive breast conditions. This study aimed to evaluate and compare ER and PR expression in perimenopausal and postmenopausal women presenting with breast lesions. Objective: The aim of the study is to examine the degree of expression of ER and PR in the endometrium of women with perimenopausal and postmenopausal bleeding. Methods: 50 endometrial biopsy and hysterectomy specimens of perimenopausal and postmenopausal bleeding from the department of obstetrics and gynaecology of RRMCH after routine tissue processing, tissue sections will be stained immunohistochemically for ER and PR receptor expression as per standard procedure with the combination of pathnsitu protocol and pressure cooker antigen retrieval (tris-EDTA buffer- pH 6) and Allred scoring system was used for interpretation. Results: In the present study, majority of the patients belong to the age group 40 - 45 years (66%). The mean age of the patients was found to be 46.80 + 6.84. All the patients with Proliferative endometrium, disordered proliferative endometrium, cystic atrophy endometrium & lytic endometrium were 100% positive for ER, followed by hyperplasia without atypia 87.5% and secretory endometrium 80%, atypical hyperplasia 66.6% and carcinoma endometrium 50.0%. All the patients with Proliferative endometrium, disordered proliferative endometrium, cystic atrophy endometrium, lytic endometrium were 100% positive for PR, followed by hyperplasia without atypia 87.5% and secretory endometrium 80%, atypical hyperplasia 66.6% and carcinoma endometrium 62.4%. A declining trend in receptor positivity was noted with advancing age and menopausal status, although not statistically significant in all subgroups. Conclusion: ER and PR expression is more frequently observed in perimenopausal women compared to postmenopausal women. Analysis of steroid hormone receptors plays an important role in patients with perimenopausal and postmenopausal bleeding to predict the response to hormonal therapy