Depletion of Peripheral Monocytes Alters Long-Term Gene Expression in Microglia in a Murine Model of Traumatic Brain Injury
These data show that a short course of peri-injury depletion of peripheral monocytes may have a neuroprotective effect after TBI. Alteration of the long-term transcriptional profile of microglia may be responsible for the observed changes in behavior. These data warrant further investigation into the possible therapeutic benefits of peri-injury immune modulation.
Authors
- Zhangying Chen (ORCID: https://orcid.org/0000-0001-8510-9416)
- Hiam Abdala‐Valencia (ORCID: https://orcid.org/0000-0003-3384-5299)
- Steven J. Schwulst (ORCID: https://orcid.org/0000-0003-4248-8545)
- Mecca B.A.R. Islam
- Booker T. Davis (ORCID: https://orcid.org/0000-0003-0029-7900)
- Gaurav Gadhvi (ORCID: https://orcid.org/0000-0002-4379-2824)
- Kacie P. Ford
- Talia B. Just (ORCID: https://orcid.org/0000-0002-6372-7974)
- Matthew Dapas (ORCID: https://orcid.org/0000-0002-8004-8535)
- Hadijat M. Makinde (ORCID: https://orcid.org/0000-0001-8492-4187)
Institutions
- Northwestern University (US)
- University of Michigan (US)
Publication Details
- Journal
- Shock
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1097/shk.0000000000002695
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00