CALCIUM-ION BINDING BY POLYMERIC ALENDRONATE DERIVATIVES

Water-soluble phosphorus-containing polymers of various structures have been synthesized for the first time: a homopolymer of acryloyl alendronate, its copolymers with 4-acryloylmorpholine and 2-deoxy-2-methacryl-amido-D-glucose, and a copolymer of N-vinylpyrrolidone with allyl alendronate. A comparative study of their ability to bind calcium ions has been conducted. It has been shown that for alendronate-containing polymers, the amount of Ca2+ bound by one phosphorus-containing group is 2 to 3 times higher than that of polyvinylphosphonic acid.