3,4-Dihydroxyphenylglycol levels separate multiple system atrophy from Parkinson disease with orthostatic hypotension
CSF/plasma ratios of DHPG, cardiac arteriovenous increments in plasma DHPG, and cardiac norepinephrine spillovers separate MSA from PD+OH. On the basis of our results we propose that biomarker combinations involving DHPG in biofluids may enable a clinical laboratory distinction of MSA from PD+OH.
Authors
- David S. Goldstein (ORCID: https://orcid.org/0000-0002-5709-9940)
- Courtney Holmes
- Patti Sullivan
Institutions
- National Institutes of Health (US)
- National Institute of Neurological Disorders and Stroke (US)
Publication Details
- Journal
- Clinical Autonomic Research
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1007/s10286-025-01150-8
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- NHLBI Division of Intramural Research