Suppressive effects of lovastatin on OGD/hemin-induced inflammation and ferroptosis in brain microvascular endothelial cells through the METTL3/HDAC6 cascade
Our study demonstrates that lovastatin suppresses OGD/H-induced inflammation and ferroptosis in human BMVECs through the potential METTL3/HDAC6 cascade, providing novel evidence for the neuroprotective role of lovastatin.
Authors
- Li Han (ORCID: https://orcid.org/0000-0002-2780-0978)
- Lixiong Xue (ORCID: https://orcid.org/0000-0002-3490-6498)
- Huahui Chen
- Yuanzhao Tuo
- Peng Liu (ORCID: https://orcid.org/0000-0003-3453-2278)
- Xuemin Wang (ORCID: https://orcid.org/0000-0001-8897-5344)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0003-4562-5955)
- Xinmin Ding (ORCID: https://orcid.org/0000-0001-7040-4666)
Institutions
- Army Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Shock
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1097/shk.0000000000002688
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00