Target attainment with continuously administered cefotaxime in critically ill patients – a retrospective cohort study
Our real-world analysis demonstrates that continuous administration of a standard dose of 6 g cefotaxime per day invariably ensures bactericidal plasma concentrations regarding Enterobacterales even with augmented renal function. We propose specific adjustments of daily doses for normal and reduced renal function.
Authors
- Christian Lanckohr (ORCID: https://orcid.org/0000-0003-2822-8122)
- Frank Streit (ORCID: https://orcid.org/0000-0002-3030-5388)
- Matthias Bernd Schulze (ORCID: https://orcid.org/0000-0002-0830-5277)
- Simone Scheithauer (ORCID: https://orcid.org/0000-0003-0773-4739)
- Martin Sebastian Winkler (ORCID: https://orcid.org/0000-0002-3328-5175)
- Johannes Wieditz (ORCID: https://orcid.org/0000-0001-8601-0266)
- Loris Weber
- Caspar Stephani
- Onnen Moerer (ORCID: https://orcid.org/0000-0002-4210-388X)
Institutions
- University Hospital Münster (DE)
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Journal of Critical Care
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.jcrc.2025.155264
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00