Unani Approach in the Management of Lichen Simplex Chronicus (LSC): A Case Report

Lichen Simplex Chronicus (LSC) is a chronic, localized type of neurodermatitis characterized by lichenified, hyper-pigmented plaques resulting from a self-perpetuating itch scratch cycle. Conventional treatments provide only short-term relief and are often associated with adverse effects. Prolonged use of corticosteroids can cause serious adverse effects, antihistamines offer only partial control of pruritus, and systemic drugs or phototherapy are costly and carry significant risks. Moreover, these therapies fail to address the psychological component of the itch scratch cycle, leading to frequent relapses. This case report highlights the successful use of Unani therapy in an adult female patient with LSC associated with depression, demonstrating significant clinical improvement. A 42-year-old female presented with a three-year history of itchy, hyper-pigmented, lichenified plaque over the right ankle and dorsum of the foot. She had previously undergone allopathic treatment with minimal relief. The patient was prescribed with Unani therapy comprising 10 gm of oral Majoon Najah for depression and topical Marham-e-Ra’al (twice daily) for one month. Assessment was done clinically and through validated tools, including the Physician global assessment scale (PGA) and the Hamilton Depression Rating Scale (HAM-D), at baseline and after one month of treatment. Marked resolution of lesions and pruritus was observed, with notable improvement in depressive symptoms. The therapy was well tolerated, and no adverse effects were reported. This case suggests that Unani therapy may serve as a safe, effective, and culturally acceptable alternative for managing neurodermatitis. However, further controlled studies are needed to confirm its broader efficacy.