Triterpenes From <i>Lagerstroemia indica</i> L. Bark With Anti‐ZIKV Activity
Two previously undescribed triterpenes, 2S,3R,23-trihydroxy-1-oxo-olean-12-en-28-oic acid (1) and 2S,3R-dihydroxy-1-oxo-olean-12-en-28-oic acid (2), along with 19 known triterpenes (3-21), were isolated from the bark of Lagerstroemia indica L. Their structures were determined by comprehensive spectroscopic analysis, including NMR, HR-ESI-MS, UV, and IR measurements. The absolute configurations were established through ECD calculations. Compound 4 demonstrated potent anti-ZIKV activity with an EC<sub>50</sub> value of 6.05 ± 0.51 µM. Notably, Compound 4 was shown to inhibit ZIKV envelope (E) protein expression and viral replication in a dose-dependent manner.
Authors
- Yuan‐Lin Kong
- Xue Wu (ORCID: https://orcid.org/0000-0002-2607-8717)
- Muhammad Aurang Zeb (ORCID: https://orcid.org/0000-0001-5841-3500)
- Wei‐Lie Xiao (ORCID: https://orcid.org/0000-0001-6826-1993)
- Fusakazu Ai
- Xiaoli Li (ORCID: https://orcid.org/0000-0001-8280-0877)
- Chang‐Bo Zheng (ORCID: https://orcid.org/0000-0001-6981-0210)
- Le Yi Wang (ORCID: https://orcid.org/0000-0002-1756-4633)
- Wen‐Cong Gao (ORCID: https://orcid.org/0000-0002-8427-4273)
- Xiao‐Huan Zhou
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- Yunnan Center for Disease Control And Prevention (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1002/cbdv.202502069
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 1.88