Podophyllotoxin-induced acute kidney injury via the HMGB1/TLR4/MyD88/NF-κB axis in SD rats based on the toxicological evidence chain (TEC) concept via multiomic analysis
Podophyllotoxin induces AKI through activation of the HMGB1/TLR4/MyD88/NF-κB signaling pathway. This study revealed HMGB1-mediated signaling as a key mechanism underlying the nephrotoxic effects of podophyllotoxin, identifying potential therapeutic targets to mitigate its toxicity and improve its clinical applicability.
Authors
- Yanzhao Zhang
- Mingyue Wei (ORCID: https://orcid.org/0000-0003-4982-2526)
- Zilong Chen (ORCID: https://orcid.org/0000-0003-4467-8537)
- Junjie He (ORCID: https://orcid.org/0000-0001-6447-7893)
- Hongwei Jiang (ORCID: https://orcid.org/0000-0003-0779-0693)
- Wanying Wang (ORCID: https://orcid.org/0000-0002-2901-4532)
- Baixuan Shen
- Chuanxin Liu
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Henan University of Science and Technology (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-09-17
- DOI
- https://doi.org/10.1016/j.intimp.2025.115530
- Citations
- 1
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.81